Jeffery D Molkentin Selected Research

DNA (Deoxyribonucleic Acid)

12/2019	The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.
1/2013	Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response.
10/2010	The transcription factor GATA-6 regulates pathological cardiac hypertrophy.
4/2004	MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.
4/2004	Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.
1/2004	Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction.

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Jeffery D Molkentin Research Topics

Disease

56	Cardiomegaly (Heart Hypertrophy) 11/2023 - 03/2002
54	Hypertrophy 11/2023 - 03/2002
43	Heart Failure 11/2023 - 04/2002
31	Fibrosis (Cirrhosis) 01/2023 - 04/2002
21	Cardiomyopathies (Cardiomyopathy) 11/2023 - 02/2003
17	Necrosis 01/2024 - 03/2005
16	Heart Diseases (Heart Disease) 11/2023 - 03/2002
16	Muscular Dystrophies (Muscular Dystrophy) 01/2023 - 06/2006
15	Myocardial Infarction 01/2018 - 01/2004
13	Ischemia 01/2023 - 01/2004
10	Reperfusion Injury 01/2023 - 01/2004
9	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2017 - 03/2004
8	Infarction (Infarctions) 04/2014 - 04/2004
7	Body Weight (Weight, Body) 11/2023 - 04/2002
6	Rupture 01/2020 - 08/2013
6	Inflammation (Inflammations) 10/2017 - 04/2005
5	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2023 - 06/2006
5	Ventricular Remodeling 01/2018 - 08/2007
5	Neoplasms (Cancer) 01/2012 - 07/2002
5	Infections 03/2011 - 03/2002
4	Sudden Death 01/2017 - 09/2003
4	Pancreatitis 01/2016 - 04/2012
3	Atrophy 01/2021 - 01/2010
3	Cardiac Arrhythmias (Arrythmia) 01/2020 - 09/2003
3	Cicatrix (Scar) 01/2018 - 01/2016
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 05/2016 - 03/2007
3	Thrombosis (Thrombus) 07/2010 - 02/2008
2	Muscular Atrophy (Muscle Atrophy) 04/2024 - 01/2010
2	Type 2 Diabetes Mellitus (MODY) 11/2020 - 02/2010
2	Insulin Resistance 11/2020 - 02/2013
2	Hyperglycemia 01/2020 - 02/2010
2	Pulmonary Hypertension 12/2019 - 05/2003
2	Fatigue 11/2018 - 04/2015

Drug/Important Bio-Agent (IBA)

52	CalcineurinIBA 11/2015 - 03/2002
31	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2002
18	CalciumIBA 05/2016 - 03/2002
16	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2002
14	Mitochondrial Permeability Transition PoreIBA 01/2024 - 09/2007
12	Protein Isoforms (Isoforms)IBA 01/2015 - 12/2002
11	Cyclophilins (Cyclophilin)IBA 01/2021 - 03/2005
9	Phosphotransferases (Kinase)IBA 11/2023 - 11/2002
8	Mitogen-Activated Protein KinasesIBA 11/2020 - 04/2004
8	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2019 - 03/2002
8	PeriostinIBA 01/2017 - 08/2007
7	Transforming Growth Factors (Transforming Growth Factor)IBA 04/2024 - 02/2011
7	Angiotensin IIIBA 11/2023 - 11/2002
7	CollagenIBA 01/2023 - 02/2009
7	CytokinesIBA 10/2018 - 04/2005
7	Sarcoglycans (beta Sarcoglycan)IBA 12/2014 - 06/2006
6	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2024 - 02/2008
6	DNA (Deoxyribonucleic Acid)IBA 12/2019 - 01/2004
6	DystrophinIBA 05/2016 - 01/2007
6	Protein Kinases (Protein Kinase)IBA 01/2015 - 08/2006
6	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2012 - 05/2003
6	Cyclosporine (Ciclosporin)FDA LinkGeneric 02/2011 - 04/2002
6	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 02/2009 - 01/2004
5	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2020 - 05/2002
5	Protein Kinase CIBA 01/2018 - 02/2007
5	p38 Mitogen-Activated Protein KinasesIBA 08/2017 - 05/2003
5	LuciferasesIBA 09/2015 - 05/2003
5	Histone Deacetylases (Histone Deacetylase)IBA 04/2013 - 03/2006
4	RNA (Ribonucleic Acid)IBA 10/2021 - 11/2017
4	Messenger RNA (mRNA)IBA 01/2020 - 02/2006
4	DesminIBA 10/2018 - 12/2010
4	Tamoxifen FDA LinkGeneric 01/2017 - 02/2005
4	Adenosine Triphosphate (ATP)IBA 01/2016 - 03/2008
4	MyostatinIBA 01/2016 - 06/2006
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2016 - 11/2002
4	Tacrolimus (Prograf)FDA LinkGeneric 09/2015 - 03/2002
4	Calcineurin InhibitorsIBA 09/2015 - 03/2002
4	Peptides (Polypeptides)IBA 10/2011 - 02/2006
4	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 07/2011 - 05/2003
4	cysteine and glycine-rich protein 3IBA 08/2006 - 03/2004
3	Complementary DNA (cDNA)IBA 01/2021 - 02/2003
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 03/2011
3	IntegrinsIBA 01/2019 - 08/2010
3	Transforming Growth Factor beta (TGF-beta)IBA 10/2018 - 02/2006
3	Crystallins (Crystallin)IBA 10/2018 - 09/2014
3	ruboxistaurinIBA 12/2017 - 07/2009
3	Creatine Kinase (Creatine Phosphokinase)IBA 03/2016 - 03/2011
3	ChemokinesIBA 01/2016 - 04/2005
3	Adenosine Triphosphatases (ATPase)IBA 01/2015 - 04/2009
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2013 - 11/2002
3	Insulin (Novolin)FDA Link 01/2013 - 01/2004
3	Serine (L-Serine)FDA Link 07/2011 - 10/2004
3	salicylhydroxamic acid (SHAM)IBA 02/2011 - 08/2007
3	transcription factor NF-AT c3IBA 10/2008 - 06/2003
2	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2024 - 12/2010
2	Activating Transcription Factor 4IBA 04/2024 - 01/2021
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2023 - 11/2018
2	GlucocorticoidsIBA 01/2023 - 01/2022
2	Glucose (Dextrose)FDA LinkGeneric 11/2020 - 02/2011
2	Dual-Specificity PhosphatasesIBA 11/2020 - 04/2004
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2020 - 03/2006
2	Transforming Growth Factor-beta Type II ReceptorIBA 12/2018 - 10/2018
2	Carrier Proteins (Binding Protein)IBA 12/2018 - 01/2016
2	Extracellular Matrix ProteinsIBA 01/2018 - 01/2009
2	Fibronectins (Fibronectin)IBA 01/2018 - 01/2012
2	Glycoproteins (Glycoprotein)IBA 01/2018 - 03/2016

Therapy/Procedure

7	Therapeutics 04/2022 - 05/2004